Endocrine Abstracts

Purpose: To evaluate the outcome of different Radioactive iodine-131 activity range for the treatment of hyperthyroidism assessed at 6 and 12 months.Material/method: We retrospectively reviewed data of patients who received Radioiodine treatment for benign thyroid disorder at our center between 2013 to 2015. Indication for treatment, radioiodine activity administered, type of hyperthyroidism, and biochemical outcome of thyroid function at 6 and 12 months...

Background: Insulin autoimmune syndrome (IAS) is characterised by spontaneous hypoglycaemia in the absence of exogenous insulin administration and high serum levels of immunoreactive insulin along with high titres of insulin antibodies. Although it is the third leading cause of hypoglycaemia in Japan, it is very rare in the western world. We present the first reported case of IAS in UK.Case report: A 27-year-old lady from south east-Asian background pres...

Purpose: To evaluate long-term safety and efficacy of cinacalcet in management of primary hyperparathyroidism (PHPT).Material/Methods: We retrospectively studied all patients on cinacalcet for primary hyperparathyroidism over 3 year’s period. Data was collected and analyzed for indication, daily maintenance dose, tolerability, biochemical effect at 3, 6 and 12 months, effect on bone mineral density and renal stone disease. This study excluded those ...

Background: The treatment goal in primary hyperparathyroidism (PHPT) is the achievement of biochemical control and prevention of target organ complications. Parathyroidectomy is the current recommended intervention to cure the disease. However, Cinacalcet is an alternative medical treatment for subgroup of patients in whom surgery is deemed inappropriate, those with recurrent disease, and as bridging therapy for delayed operation particularly in recent COVID pandemic. Current ...

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Purpose: To compare effectiveness of different radioiodine activities used for the treatment of benign thyroid disease.Method: We retrospectively reviewed our local radioiodine audit data collected over 7 years duration. Patients with benign thyroid disease and known post-treatment biochemical outcomes were included. Data were analysed for primary diagnosis, activity dose, and biochemical outcomes in 6 and 12 months post-treatment....

Introduction: Generously supported by IPSEN)-->Insulin tolerance test (ITT) is considered as the gold standard assessment for hypothalamic–pituitary–adrenal axis (HPA) integrity. Short synacthen test (SST) is a relatively simple, low-cost and well tolerated first line test of HPA despite concerns regarding accuracy. The glucagon stimulation test (GST) is often used as an alternative to the ITT. Although less reliable, it is...

Background: The exact changes of hormones and the relative importance of these to the metabolic improvement after bariatric surgery remain to be explored. We highlight the unusual case of a patient who developed episodes of angioedema post roux-en-y surgery for weight reduction.Case: A 38-year-old man with a BMI of 50 kg/m2, had laparoscopic Roux-en-y bypass surgery, resulting in 89 kg loss over 12–18 months. Six to twelve 12 months post-...

Introduction: Carcinoid tumours commonly originate from the gastrointestinal tract. Cardiac manifestations occur in 10–41% of patients with carcinoid syndrome, usually associated with liver metastases. We report an atypical case of a carcinoid tumour associated with right sided heart disease without distant metastases.Case description: A 75-year-old lady with no significant past medical history and a lifelong non-smoker, was admitted with 3 months h...